Experiments on animals are necessary for drug discovery and development as well as to advance pharmaceutical, medical and biomedical research. The best means to extrapolate from animal dose to human dose or human dose to animal dose has been an area of interest in experimental pharmacology for a number of years. Dosage calculation and stock solution preparation based on dosage rationale formula are prerequisites to drug administration in experimental animals also have the utmost importance. 1) Calculate the dose for experimental animals The human or animal dose that is given to other animals is on the basis of weight or relative surface area. It has been argued that body surface area (BSA) provides a more accurate basis for dose calculation, because total body water, extracellular fluid volume, and metabolic activity are better paralleled by BSA. If the dose of a drug for an animal is unknown then it may be converted from human doses or other animal doses with the help of appropri
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