Skip to main content

Posts

DOSE CALCULATION IN PHARMACOLOGICAL EXPERIMENTS

Experiments on animals are necessary for drug discovery and development as well as to advance pharmaceutical, medical and biomedical research. The best means to extrapolate from animal dose to human dose or human dose to animal dose has been an area of interest in experimental pharmacology for a number of years. Dosage calculation and stock solution preparation based on dosage rationale formula are prerequisites to drug administration in experimental animals also have the utmost importance. 1) Calculate the dose for experimental animals The human or animal dose that is given to other animals is on the basis of weight or relative surface area. It has been argued that body surface area (BSA) provides a more accurate basis for dose calculation, because total body water, extracellular fluid volume, and metabolic activity are better paralleled by BSA. If the dose of a drug for an animal is unknown then it may be converted from human doses or other animal doses with the help of appropri
Recent posts

Maintenance of Laboratory Animals as per CPCSEA Guidelines

All establishments engaged in research and education involving animals in India are required to comply with the various guidelines, norms and stipulations set out by CPCSEA. The aim of these guidelines is to ensure humane and ethical treatment of animals, while facilitating legitimate scientific research involving experiments on animals and to make judicious use of animals for experimental purposes. Committee for Purpose of Control andSupervision of Experiments on Animals (CPCSEA): The Prevention of Cruelty to Animals Act 1960 as amended in 1982, is to prevent the unnecessary pain or suffering on animals. The Central Government has constituted a Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) which ensures that animals are not subjected to unnecessary pain or suffering before, during or after the performance of experiments on them. For this purpose, the Government has made "Breeding of and Experiments on Animals (Control and Superv